2021.09.28 14:38 EXPERT_SHADOW_L Alright it’s that time again, what should I get for 1k coupons?
2021.09.28 14:38 Delacaridad123_ I literally don’t know what to do or who to call anymore ? I’m going crazy checking this stupid portal every second of the day , I guess since everyone else got their money only like 16 of us are in this chat with no help or information .. just lost and confused
2021.09.28 14:38 smmedianews Updates and tweaks to the XP system in Fortnite Season 8
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2021.09.28 14:38 baileighw Ayyee
2021.09.28 14:38 FrontpageWatch2020 [#9|+7058|313] Companies force plastic on us with every item we buy and yet we are the only ones who seem to be made responsible for the impact on the environment . They give us the responsibility for a situation they control. [r/Showerthoughts]
2021.09.28 14:38 DanAdamsShow Mayorkas Admits How Dangerous The Haitian Migrants Are
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2021.09.28 14:38 Aralis1 Steam Will Still Let You Revert To Old Game Versions Despite Concerns
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2021.09.28 14:38 Sharkelberryfinn I spotted an ADHD in the wild
Well, sorta the wild. I started watching Girlboss on Netflix this week. As an aging hipster Millennial I loved it and recommend it.
It was funny though, because as I was watching it I kept thinking "this girl acts like she has ADHD" It was really hard for her to keep jobs, she was impulsive, had emotional outbursts, her apartment was disorganized, she was always late to things.
Turns out the real person this is based on really does have ADHD!
They don't really call out her disability in the show, and I wish they had. But it was still a very good depiction of what it can be like living like this!
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2021.09.28 14:38 footballhockeyjunky 25M - Friends, Football, & Beer
25 male here, in the Midwest and looking for some easy going friends to chat with.
I’m an engineer, flip houses on the side, and love me some football, UFC, and hockey.
Easy to talk to, can talk most of the day and hope you have common interest as me. Feel free to chat!
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2021.09.28 14:38 SongsOfLinda Has anyone worked with Minnesota Pergola?
2021.09.28 14:38 jkaz870 2 old wow players looking for a new home
I mained resto druid for many years. My friend was a mage, we had a fairly successful wow guild that I ran back in the Cata/Mop days. Normally we are active from 9pm-12am EST. Would love to get in with some experienced MMO players. We have not chosen a server so hit me up before later today.
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2021.09.28 14:38 AndrrreasK Max Yelling at a Childrens Card Game
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2021.09.28 14:38 Anyataylorjoylegs Scarlett Johansson & Keira Knightley
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2021.09.28 14:38 Chris-G-O Cardano’s Ada Wants to Solve Some of Crypto’s Biggest Challenges : WSJ
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2021.09.28 14:38 8fouachfg Looks perfect in a poster frame!
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2021.09.28 14:38 AutoNewspaperAdmin [World] - Coronavirus Hong Kong: 200 extra quarantine slots ‘nowhere near enough’ to ease city shortage of domestic helpers | South China Morning Post
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2021.09.28 14:38 killHACKS Solider comes home and surprises his best doggy friend
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2021.09.28 14:38 BrautanGud Russia - Government declares groups linked to Church of Scientology as ‘undesirable’
2021.09.28 14:38 DemandNormal How to use ‘dès’+ ‘dès’ instead of ‘depuis’
Could somebody please tell me how to define ‘dès’ and when it is used. I’ve seen it used to also mean ‘since’, so when is ‘dès used to mean since instead of ‘depuis’? Thanks
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2021.09.28 14:38 BritneyKassamba Need opinions
So here’s my dilemma. I am a cover driver at UPS. No route for me so they are saying I have to preload until I have work as a cover. I don’t wanna preload. Union told me I don’t have to but I have supervisors saying I have to because it’s still my main title and I only drive when they need me to. I had to district manager messaging me saying I am expected to preload. At this point I rather leave than do that because that was my intentions at first but decided to apply for a driving position instead of leaving the company. Good company with good benefits but the preloading thing is too much for me. Will I ever be able to wait until I get a route and do my thing ,work wise outside of ups until they are ready for me , or do I go ahead and try to apply for another job ??
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2021.09.28 14:38 TruckingAngler SNGX 9/28: Soligenix Announces Accelerated Publication Demonstrating Efficacy and Broad Neutralizing Activity of its COVID-19 Vaccine in Non-Human Primates.
September 28 2021 - 07:30AM. "PRINCETON, N.J., Sept. 28, 2021 - Soligenix, Inc. (Nasdaq: SNGX) a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need, announced today publication of pre-clinical immunogenicity studies for CiVax™ (heat stable COVID-19 vaccine program) demonstrating durable broad-spectrum neutralizing antibody responses, including against the Beta, Gamma and Delta variants of concern. The article, titled "Protein Vaccine Induces a Durable, More Broadly Neutralizing Antibody Response in Macaques than Natural Infection with SARS-CoV-2 P.1," has been posted as an accelerated preprint on bioRxiv (available here). The manuscript is part of the ongoing collaboration with Axel Lehrer, PhD, Associate Professor at the Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine (JABSOM), University of Hawai?i at Manoa (UHM). Development continues under a non-dilutive $1.5M Small Business Innovation Research (SBIR) grant from the National Institute of Allergy and Infectious Diseases (NIAID) awarded to Soligenix in December 2020.
"This technology platform has previously demonstrated an encouraging ability to generate vaccines that are stable at ambient temperature, potentially avoiding the need for refrigerated or frozen storage and distribution," said Jerome Kim, MD, Director General of the International Vaccine Institute. "The encouraging development of a broadly neutralizing and efficacious subunit vaccine specifically for SARS-CoV-2, including the variants of concern, using the same heat stable technology platform offers greater promise for achieving worldwide vaccination in the current pandemic."
"We continue to advance our work using our vaccine platform, consisting of a robust protein manufacturing process and a thermostabilizing formulation, using the Soligenix ThermoVax® process and the CoVaccine HT™ adjuvant. The CiVax™ vaccine has demonstrated broad and robust immune responses in mice, which is recapitulated here in NHPs and further shown to yield protection against infection with COVID-19 variants of concern. Our work with CiVax™ emerged from our ongoing efforts to develop heat-stable, single-vial format vaccines for filoviruses. The ability to rapidly pivot from filovirus to SARS-CoV-2 demonstrates the broad applicability of this platform and our productive collaboration with Soligenix," stated Dr. Lehrer. "A single-vial subunit vaccine that can be shipped at ambient temperatures and that need only be reconstituted with sterile water immediately prior to use has the potential to bolster the global vaccination efforts by simplifying storage and distribution logistics."
"We believe that creating a COVID-19 vaccine, like CiVax™, with enhanced stability at elevated temperatures has the potential to lead to a faster resolution of this global pandemic, curtailing the further evolution of the virus," stated Christopher J. Schaber, PhD, President and Chief Executive Officer of Soligenix. "Moreover, the introduction of a subunit vaccine that has been built on years of proven vaccine technology may also encourage the vaccine-hesitant. This platform not only has the potential to aid in the current worldwide pandemic; but the technology platform, with its broad applicability, may also aid in the preparation for future pandemics. With these latest results, we will be expanding discussions with various funding agencies in the coming weeks."
CiVax™ is the Company's heat stable subunit vaccine candidate for the prevention of COVID-19, the disease caused by infection with SARS-CoV-2. Ongoing collaborations with Dr. Lehrer have confirmed the feasibility of developing a broadly immunogenic vaccine for COVID-19. A full-length Spike protein antigen coupled with liquid or lyophilized (thermostabilized) CoVaccine HT™ adjuvant has been tested for immunogenicity and efficacy in the context of Gamma variant challenge in non-human primates (NHPs). NHPs were vaccinated twice, three weeks apart, and were subsequently challenged with Gamma variant both intranasally and intratracheally 12 weeks later. While most vaccines tested in NHPs use a challenge date only four weeks post-vaccination when antibody levels are peaking, the use of a later challenge time in this study demonstrates the durable response elicited by this vaccine candidate. While the vaccine antigen is developed based on the Spike protein of the original SARS-CoV-2 strain, it elicited cross-neutralizing antibodies against Beta, Gamma and Delta variants of concerns. After challenge, vaccinated animals had a lower peak viral load and more rapid resolution of infectious virus, coupled with reduced lung damage. After challenge with Gamma variant, animals that were not vaccinated with CiVax™ generated a neutralizing antibody response to Beta and Gamma variants but not to the original strain and the Delta variant, demonstrating that natural infection may not yield sufficiently robust immunity. In stark contrast, CiVax™-vaccinated animals subsequently challenged with Gamma variant had enhanced neutralizing antibody responses against the original strain, as well as the Beta, Gamma and Delta variants.
While a number of vaccines are available worldwide, the requirement for cold chain shipping and timely administration, coupled with manufacturing scale-up logistics, have limited the world's supply. Rapid vaccine administration worldwide is necessary to curtail disease spread and slow or pre-empt evolution of mutations, which may abrogate the effectiveness of current vaccine approaches. Previous work with the novel CoVaccine HT™ adjuvant has indicated that it can be thermostabilized both alone and in combination with antigens, potentially yielding a single-vial presentation of CiVax™, which would not require cold chain distribution or storage."
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2021.09.28 14:38 TexasMom885 Just a 35 yo mom who hopes ya have a great day!!!!!
The best way to predict the future is to create it for yourself!!!! Dream big and go for it! Yes we may fail but it's so much better than not trying!!!
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2021.09.28 14:38 ky123yoyo Could someone photoshop the hat, watch, and chain on this snail
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2021.09.28 14:38 haveumetted2 So, there’s a Central Asia, a South Asia, and a Southeast Asia - but why is there no West Asia?
2021.09.28 14:38 deadtank 16% off all LPs! Over 500 titles to choose from! Promo code in link.
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